个人简介

武汉纺织大学省部共建国家重点实验室徐卫林院士团队骨干成员，武汉英才“优秀青年人才”。华中科技大学生物医学工程专业硕博连读（师从赵元弟教授，2016-2022）。参与国家自然科学基金面上项目3项、国家重点研发计划1项。在Nat. Commun.、Adv. Funct. Mater.、Chem. Eng. J.、ACS Appl. Mater. Inter.和Biomaterials等杂志发表学术论文14篇，其中第一作者7篇。获得授权发明专利2项。任SCI期刊Frontiers in Bioengineering and Biotechnology(IF= 6.06)客座编委。

研究领域

1.基于多功能纳米纤维的一体化诊疗平台在原位结直肠癌中的应用。

2.原位生长脱细胞生物补片用于疝气修复。

3.功能化外泌体构建生物医用材料用于骨修复。

主持项目

1.科技部科技援外项目，2025.09，科技部国际合作司，30万

2.湖北省自然科学基金青年B类，2025.01，湖北省科技厅，10万

3.钢铁工业环境保护全国重点实验室开放课题，2026.01，8万

4.人畜共患传染病重症诊治全国重点实验室开放课题，2025.09，5万

代表性论文

1.Ruo-Yun Zhang, et al. Biomimetic-materials Degradation for synergistic enhanced photothermal-gas Starving therapy through regulating endogenous energy-metabolism fluorescence imaging under deep-hypothermia.Nature Communications2022, 13(1), 1-18 (IF=17.69, TOP期刊，第一作者）

2.Ruo-Yun Zhang, et al. Biomimetic O2self-generated hybrid membrane nanoplatform for blocking the polarization towards immunosuppressive M2 macrophage phenotype and enhancing sonodynamics therapy in orthotopic colorectal cancer.Chemical Engineering Journal2022, 450, 138337. (IF= 16.74, TOP期刊，第一作者)

3.Ruo-Yun Zhang, et al. Bismuth particles imbedded degradable nanohydrogel prepared by one-step method for tumor dual-mode imaging and chemo-photothermal combined therapy.Chemical Engineering Journal2019, 375: 122000. (IF= 16.74, TOP期刊，第一作者)

4.Ruo-Yun Zhang, et al. One-for-all nanoplatform for synergistic mild cascade-potentiated ultrasound therapy induced with targeting imaging-guided photothermal therapy.ACS Applied Materials & Interfaces2020, 12(36): 40052-40066. (IF= 10.38, TOP期刊，第一作者)

5.Ruo-Yun Zhang, et al. Multifunctional nanocarrier with self-catalytic production of nitric oxide for fluorescence imaging-guided photothermal and gas combined therapy of tumor.Journal of Colloid and Interface Science2022, 621, 77-90. (IF= 9.96, TOP期刊，第一作者)

6.Ruo-Yun Zhang, et al. A pH/ultrasonic dual-response step-targeting enterosoluble granule for combined sonodynamic-chemotherapy guided via gastrointestinal tract imaging in orthotopic colorectal cancer.Nanoscale2021, 13(7): 4278-4294. (IF= 8.31, TOP期刊，第一作者)

7.Ruo-Yun Zhang, et al. Folic acid modified Pluronic F127 coating Ag2S quantum dot for photoacoustic imaging of tumor cell-targeting.Nanotechnology2018, 29: 055101. (IF= 3.95, TOP期刊，第一作者)

8.Yang Xuan, Ruo-Yun Zhang, et al. Ultrafast synthesis of gold nanosphere cluster coated by graphene quantum dot for active targeting PA/CT imaging and near-infrared laser/pH-triggered chemo-photothermal synergistic tumor therapy,Chemical Engineering Journal2019, 369: 87-99. (IF= 16.74, TOP期刊)

9.Yang Xuan, Ruo-Yun Zhang, et al. Targeting N-doped graphene quantum dot with high photothermal conversion efficiency for dual-mode imaging and therapyin vitro,Nanotechnology2018, 29, 355101. (IF= 3.95, TOP期刊)

10.Xiao-Quan Yang, Ruo-Yun Zhang, et al. High-security multifunctional nano-bismuth-sphere-cluster prepared from oral gastric drug for CT/PA dual-mode imaging and chemo-photothermal combined therapyin vivo,Advanced Functional Materials,2019, 29, 1900017. (IF= 19.92, TOP期刊)

11.Xiao-Shuai Zhang, Ruo-Yun Zhang, et al. A multifunctional targeting probe with dual-mode imaging and photothermal therapy usedin vivo,Journal of Nanobiotechnology2018, 16, 42. (IF= 9.42, TOP期刊)

12.Kai Cheng, Ruo-Yun Zhang, et al. Hitherto-Unexplored photodynamic therapy of Ag2S and enhanced regulation based on polydopaminein vitroandvivo,Chemistry-A European Journal2019, 25, 7553-7560. (IF= 5.02, TOP期刊)

13.An Jie, Zhang Ruo-Yun, et al. A pH/ultrasound dual-response biomimetic nanoplatform for nitric oxide gas-sonodynamic combined therapy and repeated ultrasound for relieving hypoxia.Biomaterials2020, 230, 119636. (IF= 15.34, TOP期刊)

14.Cheng Kai, Zhang Ruo-Yun, et al. High-security nanocluster for switching photodynamic combining photothermal and acid-induced drug compliance therapy guided by multimodal active-targeting imaging.Advanced Functional Materials2018, 28(36): 1803118. (IF= 19.92, TOP期刊)

15. Ruo-Yun Zhang, et al. Injectable anti-inflammatory nanofiber hydrogel reprograms immunosuppressive tumor microenvironment via cascade-amplified immunogenic cell death, Chemical Engineering Journal, 2026, 530: 1-16. (IF= 13.2, TOP期刊)

16. Ruo-Yun Zhang, et al. M1 macrophage derived exosome for reprograming M2 macrophages and combining endogenous NO gas therapy with enhanced photodynamic synergistic therapy in colorectal cancer, Journal of Colloid And Interface Science, 2023, 654: 612-625. (IF= 9.7, TOP期刊)

17. Yang Xuan, Ruo-Yun Zhang, et al. Development of tumor marker detection and tumor treatment based on silver nanozymes, Sensors and Actuators B-Chemical 411, 2024, 411: 135692. (IF= 7.7, TOP期刊)

18. Ruoyun Zhang, et al. Detection of microplastics from food and beverage packaging materials, TrAC Trends in Analytical Chemistry, 2026, 199: 118806. (IF= 12, TOP期刊)

19. 张若筠;张德翼;张兆威;姚娜;别秉霖，一种微针/GelMA水凝胶复合疝气补片及其制备方法，CN 121360289B